Iola or IOLA may refer to:

Places in the United States Iola, Colorado, a ghost town Iola, Florida, an unincorporated community Iola, Illinois, a village Iola, Kansas, a city Iola, Pennsylvania, a census-designated place Iola, Texas, a city Iola, Wisconsin, a village Iola (town), Wisconsin, a town next to or partially within the village

Given name People Iola Evans (born 1994), English actress Iola Fuller (1906–1993), American writer Iola Gregory (1946–2017), Welsh actress Iola Abraham Ikkidluak (1936–2003), Inuk artist Iola Johnson (born 1950), American news anchor Iola, pen name of American writer Ida B. Wells

Fictional characters Iola Boylan, on the television series Mama's Family the title protagonist of Iola Leroy, a novel by Frances Harper Iola Morton, girlfriend of Joe Hardy in the Hardy Boys novels Iola, a mute temple servant in The Witcher story collection The Last Wish

Other uses Iola (steamboat 1885), active on Puget Sound from 1885 to 1915 Interest on Lawyer Trust Accounts, a method of raising money for charitable purposes in the United States Myrmarachne, a genus of jumping spiders