Mossfennan is a small settlement in southern Scotland near Drumelzier in the Scottish Borders, in the valley of the River Tweed.

Mossfennan is a wooded area part of the parish of Glenholm. There was once a peel tower at Mossfennan. Also near Mossfennan are the remains of a Bronze Age burial cairn.Biggar Archaeology Woodend Report When the Talla Railway was built there was a spectacular overhead sheep crossing at Mossfennan which consisted of six concrete piers and a long ramps at right angles to the railway track.

Mossfennan appears in literature being referenced in an old Scottish ballad.Robert Chambers The popular rhymes of Scotland: with illustrations W. Hunter, 1826 'The King rode round the Merecleuch Head, Wi' spotted hounds and spaniels three, Then lichted doun at Mossfennan Yett, A little below the Logan Lee.'

John Veitch also describes the locality in The Hart of Mossfennan

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