2,3-Dichlorophenylpiperazine

2,3-Dichlorophenylpiperazine (2,3-DCPP or DCPP) is a chemical compound from the phenylpiperazine family. It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine (mCPP), though it has been shown to act as a partial agonist of the dopamine D2 and D3 receptors.

Legality 2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples.A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása

List of derivatives Aripiprazole Cariprazine BAK 2-66 Brilaroxazine (formally RP5063) FAUC-365 [474432-66-1] CJB-090 2xHCl [595584-40-0] NGB 2849 [189061-11-8] NGB 2904 Fb: [189061-11-8] HCl: [189060-98-8] PG-01037 2xHCl: [675599-62-9] PG648 Aripiptranyl (Abilifarnate)

PGX-2000001 So-called R-22 So-called JJC 7−065 R-PG-648

Positional Isomer

The positional isomer 3,4-dichlorophenylpiperazine (3,4-DCPP) is also known, and acts as both a serotonin releaser via the serotonin transporter, and a β1-adrenergic receptor blocker, though with relatively low affinity at both targets.

See also Substituted piperazine Phenylpiperazine ortho-Bromophenylpiperazine

References

External links