Kim Clijsters defeated Venus Williams in the final, 6–2, 6–1 to win the women's singles tennis title at the 2010 Miami Open. It was her second Miami Open title.

Victoria Azarenka was the defending champion, but lost to Clijsters in the fourth round.

Seeds All seeds receive a bye into the second round.

Draw

Finals

Top half

Section 1

Section 2

Section 3

Section 4

Bottom half

Section 5

Section 6

Section 7

Section 8

External links Draw and Qualifying draw