William Preston may refer to:
William Preston (actor) (1921–1998), American actor William Preston (Freemason) (1742–1818), Scottish author of Illustrations of Masonry William Preston (Kentucky soldier) (1816–1887), U.S. politician, ambassador, and Confederate officer William Preston (poet) (1753–1807), Irish poet William Preston (Virginia soldier) (1729–1783), Irish-born frontier Virginia leader, signer of the Fincastle Resolutions William Preston (Royal Navy officer), captain in the British Royal Navy who, along with James Stirling, was responsible for the foundations of Perth and Fremantle in Western Australia William Preston (British politician) (1874–1941), Conservative M.P. for Walsall, 1924–1929 William Alfred Preston (1848–1944), MPP in Ontario, Canada William B. Preston (Mormon) (1830–1908), presiding bishop of the Church of Jesus Christ of Latter-day Saints, 1884–1907 William B. Preston (1805–1862), U.S. politician from Virginia USS William B. Preston, a United States Navy Clemson-class destroyer William C. Preston (1794–1860), U.S. politician from Pennsylvania who was a U.S. senator for South Carolina William G. Preston (1842–1910), American architect William Preston (bishop) (1729–1789), Anglican bishop in Ireland William Edward Hayter Preston (1891–1964), British literary editor, journalist, poet and author Billy Preston (1946–2006), American musician Billy Preston (album), 1976 Billy Preston (basketball) (born 1997), American basketball player Bill Preston (1893–1954), American football tackle Willie Preston (born 1985), member of the Illinois Senate
Fictional Sergeant William Preston of the Northwest Mounted Police, lead character in the radio and TV series Challenge of the Yukon