Manolache may refer to several entities in Romania:
Manolache, a village in Glina Commune, Ilfov County Odaia Manolache, a village in Vânători Commune, Galați County Valea Manolache River Manolache Costache Epureanu (1823–1880), politician Cicerone Manolache (1936–2024), footballer Ionela Târlea (born 1976), formerly Ionela Târlea-Manolache, track and field athlete Luca Manolache (2005–2025), footballer