Ayew is a surname. Notable people with the surname include:
Abédi Ayew, better known professionally as Abedi Pele (born 1964), Ghanaian footballer, or his sons: Ibrahim Ayew (born 1988), Ghanaian footballer André Ayew (born 1989), Ghanaian footballer Jordan Ayew (born 1991), Ghanaian footballer Kwame Ayew (born 1973), Ghanaian footballer