Johan Alexander Santana Araque (; born March 13, 1979) is a Venezuelan former professional baseball starting pitcher. Santana pitched in Major League Baseball (MLB) for the Minnesota Twins from 2000 to 2007 and for the New York Mets from 2008 to 2012. A two-time Cy Young Award winner with the Twins, Santana is a four-time All-Star and earned a pitching triple crown in 2006. On June 1, 2012, Santana pitched the first no-hitter in New York Mets history against the St. Louis Cardinals.

Professional career Santana was discovered in 1994 by Andres Reiner, who was a scout working for the Houston Astros at the time. Santana's parents agreed to let him attend Houston's academy in Valencia. When Astros scouting director Dan O'Brien called Reiner and asked if he had signed Santana to a contract, Reiner reported that he was still deciding if Santana was a better prospect as an outfielder or a pitcher. After six weeks of training, Santana was told he was going to pitch. Santana did not like it and almost left, but Reiner convinced him to stay. While originally a center fielder, Santana was converted to a pitcher at the academy due to his arm speed. In 1999 he was named the Tovar Mérida Athlete of the Year.

Minnesota Twins After the 1999 major league season, Santana was left unprotected by the Houston Astros and eligible in the Rule 5 draft. The Minnesota Twins had the first pick that year, the Florida Marlins had the second. The Twins made a deal with the Marlins: the Twins would draft Jared Camp with their first pick and the Marlins would draft Santana. The teams would exchange the two players with the Twins receiving $50,000 to cover their pick.

Santana made his Major League debut with the Twins on April 3, 2000, coming from the bullpen vs. Tampa Bay. He made his first MLB start on April 7, 2000, at Kansas City and recorded his first Major League win in a relief appearance at Houston on June 6. He put up a 6.49 ERA in 86 innings pitched in 2000.

In 2002, the Twins sent Santana to the minors for 2 months to work almost exclusively on perfecting his changeup. He did this for 10 starts and came back up to the majors with a terrific changeup to complement his very good fastball. While in the minors, pitching coach Bobby Cuellar made Santana throw at least one changeup to every batter. According to Cuellar, Santana would sometimes throw 20 in a row during games.

Santana was used as a long reliever early in his career after finding little success as a starter. In 2002, he led the majors in wild pitches, with 15.

In 2003, Santana transitioned from relief to the Twins' starting rotation after spending the first four months of the season in the bullpen. He won his last eight decisions and pitched the ALDS opening game against the Yankees.

Due to Santana's early major-league success with the Twins, a young minor-league pitcher in the Anaheim Angels' farm system also named Johan Santana changed his name to Ervin Santana in 2003; he also achieved major league success. Santana underwent minor elbow surgery following the season.

2004 season In , Santana had one of the great second half performances of the modern era. He became the first pitcher since 1961 to give up four or fewer hits in 10 straight starts, and his 13–0 record broke the old Major League second-half mark shared between Burt Hooton and Rick Sutcliffe.

Santana's other second-half numbers were equally impressive: 11.13 strikeouts per nine innings, 1.21 ERA, 4.74 hits per nine innings, and 6.73 baserunners per nine innings. In addition, Santana set a team season record with 265 strikeouts, surpassing the old 258 mark registered by Bert Blyleven in 1973.

Santana finished in good form with a 20–6 record and led the American League (AL) in strikeouts (265), ERA (2.61), strikeouts per nine innings pitched (10.46), WHIP (0.92), batting average allowed (.192), OBP (.249), SLG (.315), and OPS (.564) and walked only 54 batters in 228 innings. Opponents stole just six bases in seven attempts against him, and his 20 victories ranked him second behind only Curt Schilling's 21. He easily won the AL Cy Young Award with all 28 first-place votes.

2005 season Santana struggled in his first outing of 2005, giving up four runs in the first inning, but quickly regained his composure and returned to Cy Young-winning form in an 8–4 victory over the Seattle Mariners. In his second game, he recorded 11 strikeouts against the Chicago White Sox as the Twins won 5–2. Santana finished the season with an ERA of 2.87, second-lowest in the AL behind Indians pitcher Kevin Millwood (2.86). However, the weak Twins club of the 2005 season cost him several otherwise-winnable games, and his winning percentage fell considerably in his second full year as a starter. He threw 238 strikeouts during the season, leading the majors, and finished third in the Cy Young voting, finishing behind winner Bartolo Colón and closer Mariano Rivera.

2006 season

Santana won the pitching Major League Triple Crown, the first pitcher to do so since Dwight Gooden in . He completed the season leading the majors in ERA (2.77) and strikeouts (245), and tied Chien-Ming Wang in wins (19). He became the first pitcher to win the triple crown with fewer than 20 wins, and the first to win it with an ERA above 2.60.

Santana also led the AL in WHIP (1.00), opposing batting average (.216), and innings pitched (233.2). He continued to add to his reputation as a great second-half pitcher, losing only one game after the All-Star break while winning 10 and posting a 2.54 ERA. A brief slump cost him the opportunity to make his 20th win of the season. No pitcher in Major League Baseball won 20 games in the 2006 season, the first time in modern major league history this occurred.

Santana won his second Cy Young Award in 2006, becoming the 14th player in MLB history to win the award multiple times. He became the fifth pitcher to win the award by a unanimous vote multiple times, joining Roger Clemens, Pedro Martínez, Greg Maddux and Sandy Koufax, who accomplished the feat three times.

From 2004 to 2006, Santana led the league in strikeouts all three years, in ERA twice, and also led in several other key statistical areas. In this three-year span, he compiled a 55–19 record with an ERA of 2.75 and WHIP of 0.96, while striking out 748 batters.

2007 season After a slow start, with his record falling to 6–6 at one point, Santana jump-started his season with a four-hit shutout, followed by two wins. On July 1, , Santana was named as a member of the 2007 All-Star Game, his third straight appearance. On June 19, 2007, on the team bus to a game at Shea Stadium, Bert Blyleven said he would have his head shaved if that night's starting pitcher, Santana, threw a complete-game shutout. The Twins won, 9–0, and Santana went the distance on a four-hitter. Santana shaved Blyleven's head the following day. Santana had perhaps his best career game on August 19 against the Texas Rangers in which he struck out 17 batters over eight innings. He walked none and allowed only two hits, both to Sammy Sosa. His 17 strikeouts set a Twins club record for strikeouts in a game. Santana's game score of 95 is the highest by any pitcher in MLB history in a non-complete game.

He led the major leagues in home runs allowed (33) and had the most losses of his career (13). Santana finished the season with only 15 wins, his lowest total since 2003. However, Santana led the AL in WHIP, was second in strikeouts with 235, and seventh in ERA. In the last game of the season, a rain delay in a road game against the Detroit Tigers that lasted over an hour caused Santana to pitch only three innings. This ended a 123 consecutive start streak in which he pitched five innings or more. This is the third-longest consecutive-game streak for a pitcher in the past half-century. In November, it was announced Santana was awarded the AL Gold Glove Award for pitcher, his first selection. He was also honored with a Fielding Bible Award as the best fielding pitcher in MLB, and finished 5th in the AL Cy Young Award voting.

New York Mets

2008 season On February 2, 2008, Santana was traded from the Twins to the New York Mets for Carlos Gómez, Philip Humber, Deolis Guerra, and Kevin Mulvey. The Mets and Santana agreed to a six-year, $137.5 million contract. Santana was named the Opening Day starter, throwing 100 pitches in seven innings to earn the win against the Florida Marlins. On May 10, 2008, he earned his first win at Shea Stadium as a member of the New York Mets.

On June 1, 2008, Santana earned his 100th career victory, going 7.2 innings and allowing one run in a 6–1 win over the Los Angeles Dodgers.

On July 27, the day after the Mets played a 14-inning game where every pitcher in the bullpen was used, Johan pitched a complete game, striking out five and getting his first RBI as a Met against the St. Louis Cardinals, improving his record to 9–7. On August 17, 2008, Santana pitched his second complete game for his 11th win of the season, allowing only three hits while walking none and striking out 7 in a 3–0 Mets shutout over the Pittsburgh Pirates.

On September 23, Santana threw 125 pitches, a career-high to that point, in eight innings to beat the Chicago Cubs. On September 27, in the thick of a playoff race and on the final weekend of the season, Santana pitched a complete three-hit gem in a 2–0 win against the Florida Marlins on three days' rest. It was later revealed that Santana had pitched that day, and perhaps in many other starts, with a torn meniscus in his left knee, for which he underwent successful surgery on October 1, 2008.

Santana finished the 2008 regular season with a 16–7 record, posting a 2.53 ERA with 206 strikeouts, which set a Mets' single-season record for strikeouts by a left-handed pitcher, breaking Jon Matlack's 35-year record of 205 in . His 2.53 ERA led the majors and was a career-best. He also set a career-high in innings pitched and was undefeated in the second half of the season. However, he was also the victim of seven blown saves, tying for first in the majors.Chuck, Bill. 100 random things about the Red Sox, Rays, and Yankees, The Boston Globe. Published April 2, 2009. Retrieved May 2, 2009.

Santana finished in third place in the NL Cy Young Award race behind Brandon Webb and winner Tim Lincecum.

2009 season On April 7, 2009, Johan Santana started the first game for the New York Mets in the 2009 season against the Cincinnati Reds. He went 5.2 innings allowing only one earned run, going on to win. In his second start on April 12, Santana struck out 13 batters and surrendered two unearned runs over seven innings against the Florida Marlins only to lose for the first time since June 28, 2008, against the New York Yankees. On August 25 Santana was placed on the 15-day disabled list and missed the remainder of the season after having to undergo season-ending arthroscopic surgery to remove bone chips in his left elbow. Santana finished the season at a record of 13–9 with a 3.13 ERA.

In 2009, he was ranked number 3 on the Sporting News list of the 50 greatest current players in baseball, behind Albert Pujols and Alex Rodriguez. A panel of 100 baseball people, many of them members of the Baseball Hall of Fame and winners of major baseball awards, was polled to arrive at the list.

2010 season