Le Fanu is a surname, also spelled LeFanu. Notable people with the name include
Alicia Le Fanu (born 1791), Irish poet and writer Alicia Sheridan Le Fanu (1753–1817), Irish writer Henry Le Fanu (1870–1946), Anglican bishop in Australia James Le Fanu (born 1950), British physician, medical journalist and author Michael Le Fanu (1913– 1970), British Royal Navy officer, Admiral of the Fleet Nicola LeFanu (born 1947), British composer Sarah LeFanu (born 1953), Scottish academic and author Sheridan Le Fanu (1814–1873), Irish writer of Gothic tales and mystery novels Thomas Le Fanu (priest) (1784–1845), Irish Dean Thomas Le Fanu (civil servant) (1858-1945), Irish civil servant Victor Le Fanu (1865–1939), Irish rugby union player William LeFanu (1904–1995), Irish librarian