Lexington Historic District may refer to:
Lexington Historic District (Lexington, Georgia), listed on the NRHP in Oglethorpe County, Georgia Lexington Historic District (Lexington, Mississippi), NRHP-listed Uptown Lexington Historic District, Lexington, North Carolina, listed on the NRHP in Davidson County, North Carolina Lexington Historic District (Lexington, Virginia), listed on the NRHP in Lexington, Virginia Several entries on the National Register of Historic Places listings in Fayette County, Kentucky