AMDA, also known as 9-aminomethyl-9,10-dihydroanthracene, is a tricyclic compound and cyclized phenethylamine which acts as a potent and selective antagonist for the 5-HT2A receptor (Ki = 20nM). It has been used to help study the shape of the 5-HT2A protein, and develop a large family of related derivatives with even higher potency and/or selectivity.
Another related compound is AMDH, in which the central cyclohexane ring of AMDA has instead been expanded into a cycloheptane ring. As with AMDA, AMDH shows good affinity for the serotonin 5-HT2A receptor (Ki = 112nM).
See also Cyclized phenethylamine Serotonin 5-HT2A receptor antagonist SpAMDA 4-PhPr-PEA FLY (psychedelics) Atherosperminine AMMT
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