SC-5, SC5, SC 5 or variants, may refer to:
SC05, an FIPS 10-4 region code SC-05, a subdivision code for Anse Royale, Seychelles, see ISO 3166-2:SC South Carolina's 5th congressional district South Carolina Highway 5 USS Cuttlefish (SC-5) SpaceX Crew-5
Video games Soulcalibur V Space Channel 5
See also Strathcarron SC-5A