MDNA may refer to:
Mitochondrial DNA (mDNA or mtDNA), the DNA located in organelles called mitochondria Mitochondrial DNA (journal), an academic journal MDNA (album), a 2012 album by Madonna The MDNA Tour, the 2012 concert tour by Madonna to promote the album MDNA World Tour (album), the live album and video documenting the tour
See also MDMA mRNA