Diisopropylphosphate (DIPP) is an organophosphate compound with the chemical formula C6H15O4P. It is a phosphate monoester and acts as an acetylcholinesterase inhibitor through covalent interaction with the enzyme.
Chemistry Diisopropylphosphate consists of two isopropoxy groups attached to a phosphate group. It is the conjugate base of diisopropyl hydrogen phosphate and is structurally related to a number of organophosphorus compounds, including diisopropyl fluorophosphate.
Biological significance Diisopropylphosphate is formed during the hydrolysis of diisopropyl fluorophosphate (DFP), a potent organophosphorus acetylcholinesterase inhibitor. The enzyme diisopropyl-fluorophosphatase catalyzes the conversion of DFP to diisopropylphosphate and fluoride ions.
See also Diisopropyl-fluorophosphatase
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