2S or 2s may refer to:
Science 2s electron in an atomic orbital 2S, a protein-folding intermediate with two disulphide bonds
Transportation 2S gondola lift 2S, a series of Toyota S engines Birdman Chinook 2S, ultralight aircraft Southwind Airlines (IATA code), a Turkish airline
Other uses Two-spirit, a term used by some indigenous North Americans to describe certain people in their communities who fulfill a traditional third-gender (or other gender-variant) ceremonial role in their cultures IIS, a draft status abbreviation for conscription into the United States armed forces
See also 2 (disambiguation) S2 (disambiguation)