Melpomene was one of the Nine Muses in Greek mythology and a Greek female given name (popular variant: Melpo).
Melpomene may also refer to: 18 Melpomene, a main belt asteroid Heliconius melpomene, a common butterfly in South and Central America HMS Melpomene, seven ships of the Royal Navy Melpomene (plant), a genus of polypod fern Melpomene (spider) a genus of spider in the family Agelenidae Melpomene Projects, one of the Housing Projects of New Orleans Melpo Mene, an Indie pop band from Stockholm, Sweden Melpomene, a woman reported to have attempted to participate in the 1896 Olympics, possibly Stamata Revithi Melpomene, album from the band Frailty "Melpomene," Book IV of the Histories by Herodotus