Main Street Commercial Historic District or Main Street Commercial District or Main Street Historic Commercial District may refer to:
Main Street Commercial District (Dothan, Alabama), a historic district listed on the National Register of Historic Places (NRHP) in Houston County, Alabama Main Street Commercial District (Little Rock, Arkansas), a historic district listed on the NRHP in Pulaski County, Arkansas Main Street Historic Commercial District (Point Arena, California), NRHP-listed in Mendocino County Main Street Commercial District (Georgetown, Kentucky), a historic district listed on the NRHP in Scott County, Kentucky Main Street Historic Commercial District (Georgetown, Kentucky), a boundary increase to that Main Street Commercial Historic District (Kalispell, Montana), listed on the NRHP in Flathead County, Montana Main Street Commercial Historic District (Hamlet, North Carolina), listed on the NRHP in Richmond County, North Carolina Main Street Commercial Historic District (Jefferson, Wisconsin), listed on the NRHP in Jefferson County, Wisconsin Main Street Commercial Historic District (Platteville, Wisconsin), listed on the NRHP in Grant County, Wisconsin Main Street Commercial Historic District (Reedsburg, Wisconsin), listed on the NRHP in Sauk County, Wisconsin Stoughton Main Street Commercial Historic District, Stoughton, Wisconsin, listed on the NRHP in Dane County, Wisconsin Main Street Commercial Historic District (Watertown, Wisconsin), listed on the NRHP in Jefferson County, Wisconsin
See also Main Street Historic District (disambiguation)