Second Street Historic District may refer to: Second Street Historic District, part of the Central Troy Historic District in Troy, New York Second Street Historic District (Albemarle, North Carolina), a National Register of Historic Places listing in Stanly County, North Carolina Second Street Historic District (Portsmouth, Ohio), a National Register of Historic Places listing in Scioto County, Ohio
See also West Second Street Historic District (disambiguation) East Second Street Commercial Historic District (disambiguation) Greater Second Street Historic District, Ottumwa, Iowa, U.S.