Mantovano is an Italian surname. Notable people with the surname include:

Battista Mantovano (1447–1516), Italian Carmelite reformer, humanist, and poet Francesco Mantovano or Francesco Caldei (1587/88 – 22 May 1674), Italian still life painter Rossino Mantovano (16th century), Italian composer

See also Mantovan Mantovani (surname)