Negative elongation factor E

Negative elongation factor E (or NELF-E) is a protein that in humans is encoded by the NELFE gene (previously RDBP).

Function

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6.

Interactions

NELF-E has been shown to interact with: NELF-A, NELF-B, and NELF-C/D.

References

Further reading

External links