AMP—thymidine kinase () is an enzyme that catalyzes a chemical reaction that converts thymidine to thymidine phosphate by transferring a phosphate group from the cofactor, adenosine monophosphate (AMP), which is converted to adenosine.
The enzyme was characterised from cells which had been infected with Herpes simplex virus.
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is AMP:thymidine 5'-phosphotransferase. This enzyme is also called adenylate-nucleoside phosphotransferase.
See also ADP—thymidine kinase, which carries out the same reaction using ADP as phosphate donor
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