Adhesion G protein-coupled receptor F1 is a protein that in humans is encoded by the ADGRF1 gene (previously GPR110). This protein acts as a receptor for synaptamide, an omega-3 fatty acid found significantly in the brain. It is a G protein-coupled receptor which couples to Gs alpha subunit G-proteins (and potentially others).
The ADGRF1 protein is a member of the adhesion-GPCR receptor family, which is a subfamily of G protein coupled receptors. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
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