In enzymology, a tubulin—tyrosine ligase () is an enzyme that catalyzes the chemical reaction
ATP + detyrosinated α-tubulin + L-tyrosine α-tubulin + ADP + phosphate
The 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is alpha-tubulin:L-tyrosine ligase (ADP-forming).
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