HMG may refer to:
Businesses and organisations His Majesty's Government (term), a Commonwealth state's executive Government of Canada Government of Gibraltar Government of New Zealand Government of the United Kingdom Holland Media Groep, Dutch TV broadcaster Human Media Group, American multi-channel network Hyundai Motor Group, South Korean car manufacturer
Science and technology Heavy machine gun, a class of larger-caliber weapon High-mobility group, a group of proteins that act on DNA HMG-CoA, a metabolic intermediate biomolecule HMG Heat and Waterproof Adhesive Human menopausal gonadotrophin, a fertility drug Human Molecular Genetics, a scientific journal