UPR may refer to:

Unfolded protein response, a biological response in the "endoplasmic reticulum" when some proteins did not properly fold Union Pacific Railroad, a freight railroad based in Omaha, Nebraska. Universal Periodic Review of the United Nations Human Rights Council Unconditional positive regard, one of the three core conditions of "person-centered therapy" Utah Public Radio, a radio station, part of the College of Humanities and Social Sciences at Utah State University

Politics Unia Polityki Realnej, a political party in Poland Popular Republican Union (disambiguation) (French: Union Populaire Républicaine, UPR)

Progressive Union for Renewal (, UPR), a political party in Benin Union for Progress and Renewal, a political party in Guinea Ukrainian People's Republic (1917–21), former state in Eastern Europe Unitary parliamentary republic, a form of unitary states

University University of Palangka Raya, the public university in Palangkaraya, Indonesia University of Puerto Rico, the public university system of Puerto Rico, or one of its 11 campuses: University of Puerto Rico, Medical Sciences Campus University of Puerto Rico at Aguadilla University of Puerto Rico at Arecibo University of Puerto Rico at Bayamón University of Puerto Rico at Carolina University of Puerto Rico at Cayey University of Puerto Rico at Humacao University of Puerto Rico at Mayagüez University of Puerto Rico at Ponce University of Puerto Rico at Rio Piedras University of Puerto Rico at Utuado