Frank O'Neill may refer to:
Frank "Buck" O'Neill (1875–1958), American football coach Frank O'Neill (politician) (1893–1975), Australian politician and member of the New South Wales Legislative Assembly Frank O'Neill (swimmer) (1926–2024), Australian swimmer Frank O'Neill (footballer, born 1940), Irish footballer Frank O'Neill (footballer, born 1953) (1953–2024), Irish footballer Frank O'Neill (film director), director of The Overland Limited Frank O'Neill (jockey) (1886–1960), American Hall of Fame jockey Frank S. O'Neil (died 1945), American lawyer and athletic commissioner
See also Frank O'Neal (1921–1986), cartoonist