Billy Bob is the given name or nickname of:

People Billy Bob Buttons, the pen name of Edward Hugh Trayer (born 1970), British-born novelist Billy Bob Faulkingham (William Faulkingham), American politician from 2018 Billy Bob Thornton (born 1955), American film actor, writer and director

Fictional characters Billy Bob Brockali, member of the animatronic robot band the Rock-afire Explosion, voiced by Aaron Fechter

See also "Hello, Billy Bob", a song by Jon Batiste on the 2023 album World Music Radio