Shepherdson is a surname. Notable people with the surname include:
Arunah Shepherdson Abell (1806–1888), American publisher Ella Shepherdson, missionary in Australia whose name was given to Shepherdson College on Elcho Island, Northern Territory Guy Shepherdson (born 1982), Australian rugby player Harold Shepherdson (1918–1995), English football player and coach Jane Shepherdson (born 1961), British businesswoman John Shepherdson (1926–2015), British logician