Pignatelli () is an Italian surname which may refer to:
People House of Pignatelli, an aristocratic family of Naples Fabio Pignatelli (born 1953), an Italian musician Faustina Pignatelli (1705–1769), Italian scientist Luca Pignatelli (born 1962), an Italian artist Luciana Pignatelli (1935–2008), Italian jewelry designer William Pignatelli (born 1959), an American state politician from Massachusetts
Places Villa Pignatelli, a museum in Naples Santa Maria Assunta dei Pignatelli, a church in Naples