human major histocompatibility complex, class II, DR8 Haplotypes groups DQA*01:DRB1*0801 to DQA*01:DRB1*0806 Structure (See HLA-DR) Identifiers alpha *0101 Symbol(s) HLA-DRA EBI-HLA DRA*0101 Identifiers beta 1 *0801 to *0806 Symbol(s) HLA-DRB1 EBI-HLA DRB1*0801 EBI-HLA DRB1*0802 EBI-HLA DRB1*0803 EBI-HLA DRB1*0804 EBI-HLA DRB1*0805 EBI-HLA DRB1*0806 Shared data Locus chr.6 6p21.31
HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.
Serology + DR8 serological recognition of the gene products of some DRB1*08 allelesderived from IMGT/HLA DRB1* DR8 Sample allele % size (N) 0801 95 1076 0802 96 265 0803 88 230DR12 - 3% 0804 93 186 0805 >60 5 0806 >75 13
The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.
Disease associations DR8 is linked to papillary thyroid carcinomas, early onset pauciarticular juvenile chronic arthritis, primary biliary cirrhosis
by allele HLA-DRB1*0801 is linked to primary biliary cirrhosis In Mexicans DR8 is found more often in type-2 juvenile diabetes.
HLA-DRB1*0803 is also linked to primary biliary cirrhosis
Genetic Linkage DR8 Haplotypes DRA DRB1 Haplotypes *0101 *0801 *0101 DQA1 DQB1 DRB1 Haplotypes *0401 *0402 *0801 HLA-A HLA-B DRB1 Haplotypes *0000 *0000 *0801
HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.
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