James Gillis may refer to:
James Lisle Gillis (1792–1881), Democratic member of the U.S. House of Representatives from Pennsylvania James Louis Gillis (1857–1917), American librarian James Gillis (bishop) (1802–1864), Roman Catholic bishop in Scotland James Henry Gillis (1831–1910), rear admiral in the United States Navy Jim Gillis (golfer), see Maine Open
See also James Melville Gilliss (1811–1865), astronomer, United States Navy officer and founder of the United States Naval Observatory Jamie Gillis (1943–2010), American pornographic actor