De Soto commonly refers to
Hernando de Soto (c. 1500 – 1542), Spanish explorer DeSoto (automobile), an American automobile brand from 1928 to 1961
De Soto, DeSoto, Desoto, or de Soto may also refer to:
Places in the United States of America Populated places De Soto, Georgia De Soto, Illinois De Soto, Iowa De Soto, Kansas De Soto, Mississippi De Soto, Missouri De Soto, Nebraska De Soto, Wisconsin DeSoto, Indiana DeSoto, Texas, the most populous De Soto in the US
Administrative divisions De Soto Parish, Louisiana DeSoto County, Florida DeSoto County, Mississippi
Parks and geographic features De Soto National Forest in Mississippi DeSoto Falls (Alabama) DeSoto Falls (Georgia) DeSoto Lake, a lake in Georgia DeSoto National Wildlife Refuge, in Nebraska and Iowa Fort De Soto Park in St. Petersburg, Florida De Soto National Memorial in Bradenton, Florida DeSoto Site Historic State Park in Tallahassee, Florida
People de Soto (surname) Other uses The DeSoto, historic hotel in Savannah, Georgia DESOTO patrols, conducted by the U.S. Navy to collect signals intelligence in hostile waters DeSoto Records, a record label USS De Soto County (LST-1171), a post-war Landing Ship Tank of the US Navy De Soto station, Los Angeles De Soto Avenue, Los Angeles
See also Soto (disambiguation)