M53, M-53, or M.53 may refer to:
Military M53 155mm Self-Propelled Gun, an American-made tracked, self-propelled gun M53, a Hungarian submachine gun developed from the Soviet PPS-43 submachine gun; see PPS submachine gun#Variants Macchi M.53, an Italian military reconnaissance floatplane of 1928 Snecma M53, a French afterburning turbofan engine developed for the Dassault Mirage 2000 fighter M53, Yugoslav copy of the MG42 machine gun M53 Yugoslavian army compass
Roads M-53 (Michigan highway), a state highway in Eastern Michigan M53 highway (Russia), a section of the Baikal Highway in Siberia M53 motorway, a motorway in England M53 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa
Other Messier 53, a globular cluster in the constellation Coma Berenices Samsung Galaxy M53 5G, an Android smartphone by Samsung.