The 2006 Chicago White Sox season was their first since winning the World Series the season before. They finished with a record of 90–72, good enough for third place in the American League Central, six games behind the champion Minnesota Twins.
Offseason November 25, 2005: Jim Thome was traded by the Philadelphia Phillies with cash to the Chicago White Sox for a player to be named later, Aaron Rowand, and Daniel Haigwood (minors). The Chicago White Sox sent Gio González (minors) (December 8, 2005) to the Philadelphia Phillies to complete the trade. November 30, 2005: Paul Konerko was signed as a free agent with the Chicago White Sox. December 13, 2005: Rob Mackowiak was traded by the Pittsburgh Pirates to the Chicago White Sox for Damaso Marte. December 20, 2005: Javier Vázquez was traded by the Arizona Diamondbacks to the Chicago White Sox for Orlando Hernández, Luis Vizcaíno and Chris Young. January 19, 2006: Jorge Velandia and Agustín Montero was signed as a free agent with the Chicago White Sox. March 8, 2006: Jeff Bajenaru was traded by the Arizona Diamondbacks to the Chicago White Sox for Alex Cintrón. March 20, 2006: Joe Borchard was traded to the Seattle Mariners by the Chicago White Sox for Matt Thornton.
Regular season
Season standings
Record vs. opponents
Game log
|- style="background-color:#bbffbb" | 1 || April 2 || Indians || 10–4 || McCarthy (1–0) || Cabrera (0–1) || || 2:59 || 38,802 || 1–0 || box |- style="background-color:#ffbbbb" | 2 || April 4 || Indians || 2–8 || Westbrook (1–0) || García (0–1) || || 2:35 || 37,591 || 1–1 || box |- style="background-color:#ffbbbb" | 3 || April 5 || Indians || 3 – 4 || Graves (1–0) || Cotts (0–1) || || 4:00 || 33,586 || 1–2 || box |- style="background-color:#ffbbbb" | 4 || April 7 || @ Royals || 7–11 || Wood (1–0) || Garland (0–1) || || 2:51 || 23,204 || 1–3 || box |- style="background-color:#ffbbbb" | 5 || April 8 || @ Royals || 3–4 || Dessens (1–0) || Politte (0–1) || Burgos (1) || 2:47 || 18,031 || 1–4 || box |- style="background-color:#bbffbb" | 6 || April 9 || @ Royals || 3–1 || Buehrle (1–0) || Elarton (0–2) || Jenks (1) || 2:17 || 15,094 || 2–4 || box |- style="background-color:#bbffbb" | 7 || April 10 || @ Tigers || 5–3 || García (1–1) || Bonderman (1–1) || Jenks (2) || 2:14 || 44,179 || 3–4 || box |- style="background-color:#bbffbb" | 8 || April 12 || @ Tigers || 4–3 || Contreras (1–0) || Robertson (1–1) || Jenks (3) || 2:14 || 12,601 || 3–4 || box |- style="background-color:#bbffbb" | 9 || April 13 || @ Tigers || 13–9 || Garland (1–1) || Verlander (1–1) || || 3:12 || 14,027 || 5–4 || box |- style="background-color:#ffbbbb" | 10 || April 14 || Blue Jays || 7–13 || Walker (1–1) || Vázquez (0–1) || || 3:15 || 31,418 || 5–5 || box |- style="background-color:#bbffbb" | 11 || April 15 || Blue Jays || 4–2 || Buehrle (2–0) || Burnett (0–1) || Jenks (4) || 2:10 || 33,247 || 6–5 || box |- style="background-color:#bbffbb" | 12 || April 16 || Blue Jays || 6 – 4 || García (2–1) || Towers (0–3) || || 1:36 || 27,337 || 7–5 || box |- style="background-color:#bbffbb" | 13 || April 17 || Royals || 9–0 || Contreras (2–0) || Mays (0–2) || || 2:29 || 27,889 || 8–5 || box |- style="background-color:#bbffbb" | 14 || April 18 || Royals || 4–1 || Garland (2–1) || Affeldt (0–2) || Jenks (5) || 2:19 || 21,901 || 9–5 || box |- style="background-color:#bbffbb" | 15 || April 19 || Royals || 4–0 || Vázquez (1–1) || Elarton (0–4) || Jenks (6) || 2:34 || 25,459 || 10–5 || box |- style="background-color:#bbffbb" | 16 || April 21 || Twins || 7–1 || Buehrle (3–0) || Santana (0–3) || || 2:29 || 31,287 || 11–5 || box |- style="background-color:#bbffbb" | 17 || April 22 || Twins || 9–2 || García (3–1) || Radke (2–2) || || 3:01 || 38,955 || 12–5 || box |- style="background-color:#bbffbb" | 18 || April 23 || Twins || 7–3 || Contreras (1–1) || Silva (1–3) || || 2:24 || 38,102 || 13–5 || box |- style="background-color:#ffbbbb" | 19 || April 24 || @ Mariners || 3 – 4 || Mateo (2–0) || McCarthy (1–1) || || 3:07 || 20,390 || 13–6 || box |- style="background-color:#bbffbb" | 20 || April 25 || @ Mariners || 13–3 || Vázquez (2–1) || Piñeiro (2–2) || Logan (1) || 2:46 || 20,451 || 14–6 || box |- style="background-color:#ffbbbb" | 21 || April 26 || @ Mariners || 1–5 || Washburn (2–3) || Buehrle (3–1) || || 2:12 || 23,848 || 14–7 || box |- style="background-color:#bbffbb" | 22 || April 28 || @ Angels || 8–5 || García (4–1) || Weaver (1–3) || || 3:03 || 43,940 || 15–7 || box |- style="background-color:#bbffbb" | 23 || April 29 || @ Angels || 2–1 || Contreras (4–0) || Santana (3–2) || Jenks (7) || 2:24 || 40,065 || 16–7 || box |- style="background-color:#bbffbb" | 24 || April 30 || @ Angels || 6–5 || Politte (1–1) || Shields (1–2) || Cotts (1) || 2:35 || 44,135 || 17–7 || box
|- style="background-color:#bbffbb" | 25 || May 1 || @ Indians || 8–6 || Vázquez (3–1) || Lee (2–2) || Jenks (8) || 3:44 || 17,845 || 18–7 || box |- style="background-color:#ffbbbb" | 26 || May 2 || @ Indians || 1–7 || Sabathia (1–0) || Buehrle (3–2) || || 2:38 || 22,630 || 18–8 || box |- style="background-color:#bbffbb" | 27 || May 3 || Mariners || 6 – 5 || Jenks (1–0) || Woods (1–1) || || 3:16 || 27,569 || 19–8 || box |- style="background-color:#bbffbb" | 28 || May 4 || Mariners || 4–1 || Contreras (5–0) || Hernández (1–4) || Jenks (9) || 2:22 || 26,313 || 20–8 || box |- style="background-color:#ffbbbb" | 29 || May 5 || Royals || 4–5 || Dessens (2–1) || Jenks (1–1) || Burgos (4) || 2:49 || 33,628 || 20–9 || box |- style="background-color:#bbffbb" | 30 || May 6 || Royals || 9–2 || Vázquez (4–1) || Hernández (1–2) || || 2:38 || 38,593 || 21–9 || box |- style="background-color:#bbffbb" | 31 || May 7 || Royals || 3–2 || McCarthy (2–1) || Dessens (2–2) || Jenks (10) || 2:36 || 38,870 || 22–9 || box |- style="background-color:#bbffbb" | 32 || May 9 || Angels || 9–1 || García (5–1) || Gregg (2–1) || || 2:34 || 36,539 || 23–9 || box |- style="background-color:#ffbbbb" | 33 || May 10 || Angels || 5–12 || Santana (3–1) || Haeger (0–1) || Rodríguez (10) || 3:15 || 31,034 || 23–10 || box |- style="background-color:#bbbbbb" | – || May 11 || Angels ||colspan=8| Postponed (rain), |- style="background-color:#ffbbbb" | 34 || May 12 || @ Twins || 1–10 || Santana (4–3) || Garland (2–2) || || 2:26 || 30,473 || 23–11 || box |- style="background-color:#ffbbbb" | 35 || May 13 || @ Twins || 4–8 || Radke (4–4) || Vázquez (4–2) || || 2:52 || 33,021 || 23–12 || box |- style="background-color:#bbffbb" | 36 || May 14 || @ Twins || 9–7 || Buehrle (4–2) || Silva (2–6) || Jenks (11) || 3:01 || 21,796 || 24–12 || box |- style="background-color:#bbffbb" | 37 || May 15 || @ Twins || 7–3 || García (6–1) || Baker (1–4) || || 3:04 || 19,413 || 25–12 || box |- style="background-color:#ffbbbb" | 38 || May 16 || @ Devil Rays || 7–10 || Kazmir (6–2) || McCarthy (2–2) || Walker (6) || 3:11 || 11,566 || 25–13 || box |- style="background-color:#bbffbb" | 39 || May 17 || @ Devil Rays || 5–2 || Garland (3–2) || Lugo (0–2) || Jenks (12) || 2:39 || 11,607 || 26–13 || box |- style="background-color:#ffbbbb" | 40 || May 18 || @ Devil Rays || 4–5 || Hendrickson (3–2) || Vázquez (1–1) || Walker (7) || 2:40 || 11,607 || 26–14 || box |- style="background-color:#bbffbb" | 41 || May 19 || Cubs || 6–1 || Buehrle (5–2) || Maddux (5–3) || || 2:07 || 39,301 || 27–14 || box |- style="background-color:#bbffbb" | 42 || May 20 || Cubs || 7–0 || García (7–1) || Hill (0–4) || || 2:38 || 39,387 || 28–14 || box |- style="background-color:#ffbbbb" | 43 || May 21 || Cubs || 4–7 || Zambrano (3–2) || Cotts (0–2) || Dempster (8) || 2:40 || 38,645 || 28–15 || box |- style="background-color:#bbffbb" | 44 || May 22 || Athletics || 5 – 4 || Jenks (2–1) || Flores (0–1) || || 3:06 || 39,354 || 29–15 || box |- style="background-color:#bbffbb" | 45 || May 23 || Athletics || 9–3 || Vázquez (5–3) || Saarloos (2–2) || || 3:00 || 38,860 || 30–15 || box |- style="background-color:#bbffbb" | 46 || May 24 || Athletics || 3–2 || Buehrle (6–2) || Haren (4–4) || Jenks (13) || 2:31 || 38,434 || 31–15 || box |- style="background-color:#ffbbbb" | 47 || May 26 || @ Blue Jays || 2–8 || Lilly (5–4) || García (7–2) || || 2:43 || 22,729 || 31–16 || box |- style="background-color:#ffbbbb" | 48 || May 27 || @ Blue Jays || 2 – 3 || Schoeneweis (1–0) || Nelson (0–1) || || 3:32 || 30,063 || 31–17 || box |- style="background-color:#bbffbb" | 49 || May 28 || @ Blue Jays || 7–5 || Garland (4–2) || Taubenheim (0–2) || Jenks (14) || 2:50 || 35,277 || 32–17 || box |- style="background-color:#bbffbb" | 50 || May 29 || @ Indians || 11–0 || Vázquez (6–3) || Lee (3–5) || || 2:48 || 31,803 || 33–17 || box |- style="background-color:#ffbbbb" | 51 || May 30 || @ Indians || 3–4 || Sabathia (5–1) || Buehrle (6–3) || Wickman (8) || 2:43 || 20,944 || 33–18 || box |- style="background-color:#ffbbbb" | 52 || May 31 || @ Indians || 0–5 || Westbrook (5–3) || García (7–3) || || 2:46 || 21,671 || 33–19 || box
|- style="background-color:#ffbbbb" | 53 || June 1 || @ Indians || 8–12 || Cabrera (1–1) || Thornton (0–1) || || 3:06 || 20,846 || 33–20 || box |- style="background-color:#ffbbbb" | 54 || June 2 || Rangers || 3–4 || Cordero (5–3) || McCarthy (2–3) || Otsuka (10) || 2:54 || 32,802 || 33–21 || box |- style="background-color:#bbffbb" | 55 || June 3 || Rangers || 8–6 || Vázquez (7–3) || Padilla (5–4) || Jenks (15) || 3:20 || 38,697 || 34–21 || box |- style="background-color:#ffbbbb" | 56 || June 4 || Rangers || 2–10 || Rheinecker (2–0) || Buehrle (6–4) || || 2:26 || 35,915 || 34–22 || box |- style="background-color:#bbffbb" | 57 || June 6 || Tigers || 4–3 || McCarthy (3–3) || Rodney (4–2) || Jenks (16) || 2:42 || 37,192 || 35–22 || box |- style="background-color:#bbffbb" | 58 || June 7 || Tigers || 4–3 || Contreras (6–0) || Verlander (7–4) || Jenks (17) || 2:31 || 37,612 || 36–22 || box |- style="background-color:#ffbbbb" | 59 || June 8 || Tigers || 2–6 || Rogers (8–3) || Garland (4–3) || || 2:29 || 37,354 || 36–23 || box |- style="background-color:#bbffbb" | 60 || June 9 || Indians || 5–4 || Thornton (1–1) || Betancourt (0–2) || Jenks (18) || 2:50 || 33,909 || 37–23 || box |- style="background-color:#bbffbb" | 61 || June 10 || Indians || 4 – 3 || Montero (1–0) || Wickman (1–1) || || 3:29 || 36,265 || 38–23 || box |- style="background-color:#ffbbbb" | 62 || June 11 || Indians || 8–10 || Westbrook (6–3) || García (7–4) || Wickman (9) || 3:13 || 34,410 || 38–24 || box |- style="background-color:#bbffbb" | 63 || June 12 || @ Rangers || 8–3 || Contreras (7–0) || Koronka (4–4) || || 2:40 || 29,182 || 39–24 || box |- style="background-color:#bbffbb" | 64 || June 13 || @ Rangers || 5–2 || Garland (5–3) || Loe (3–6) || Jenks (19) || 2:43 || 18,354 || 40–24 || box |- style="background-color:#ffbbbb" | 65 || June 14 || @ Rangers || 0–8 || Padilla (6–4) || Vázquez (7–4) || || 2:23 || 28,776 || 40–25 || box |- style="background-color:#bbffbb" | 66 || June 15 || @ Rangers || 8–2 || Buehrle (7–4) || Rheinecker (2–1) || || 2:35 || 19,424 || 41–25 || box |- style="background-color:#bbffbb" | 67 || June 16 || @ Reds || 12–4 || García (8–4) || Claussen (3–8) || || 2:37 || 32,673 || 42–25 || box |- style="background-color:#bbffbb" | 68 || June 17 || @ Reds || 8–6 || Thornton (2–1) || Coffey (3–1) || Jenks (20) || 3:09 || 39,451 || 43–25 || box |- style="background-color:#bbffbb" | 69 || June 18 || @ Reds || 8–1 || Garland (6–3) || Harang (7–5) || || 2:35 || 31,569 || 44–25 || box |- style="background-color:#bbffbb" | 70 || June 20 || Cardinals || 20–6 || Vázquez (8–4) || Mulder (6–5) || || 3:23 || 39,463 || 45–25 || box |- style="background-color:#bbffbb" | 71 || June 21 || Cardinals || 13–5 || Buehrle (8–4) || Marquis (9–5) || || 2:20 || 37,897 || 46–25 || box |- style="background-color:#bbffbb" | 72 || June 22 || Cardinals || 1–0 || García (9–4) || Reyes (1–1) || Jenks (21) || 2:00 || 39,509 || 47–25 || box |- style="background-color:#bbffbb"