Mbu may refer to:
People
Joe Mbu, rugby league coach Joe Mbu (footballer), Scottish footballer Joey Mbu, American football player Joseph Mbu, Nigerian rugby union player Matthew Mbu, Nigerian politician
Fish
Mbu pufferfish, freshwater pufferfish
Other
Macintosh Business Unit, Division of Microsoft Marble Blast Ultra, a video game for Xbox 360 MRC Mitochondrial Biology Unit, a mitochondrial research centre in Cambridge Scotch MBU {Master Broadcast U-Matic}, a brand of U-Matic video tape.