James III may refer to:
James III of Cyprus (1473–1474) James III of Majorca (c. 1315–1349) James III of Scotland (1451–1488) James III, Margrave of Baden-Hachberg (1562–1590) James Francis Edward Stuart (1688–1766), pretender who styled himself James III of England and Ireland, and James VIII of Scotland
Fictional characters James III, King of the United Kingdom in the film Red, White & Royal Blue (2023)