Orthotrichaceae is the only family of mosses in the order Orthotrichales. Many species in the family are epiphytic.

Genera Accepted genera include:Orthotrichaceae in GBIF Secretariat (2023). GBIF Backbone Taxonomy. Checklist dataset https://doi.org/10.15468/39omei. Accessed 23 April 2025. Amphoridium Atlantichella Australoria Bryomyces Cardotiella Ceuthotheca Codonoblepharon Desmotheca Florschuetziella Groutiella Leiomitrium Leratia Lewinskya Macrocoma Macromitrium Matteria Nyholmiella Orthotrichum Pentastichella Plenogemma Pulvigera Rehubryum Schlotheimia Sehnemobryum Stoneobryum Uleastrum Ulota Zygodon

Formerly included Leptodontiopsis – synonym of Zygodon Pleurorthotrichum – synonym of Pentastichella

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