E6, E06, E.VI or E-6 may refer to:

Science and technology E6 series (number series), of preferred numbers for electronic components E6 (mathematics), an exceptional Lie group, or its Lie algebra E6 polytope, in geometry Thyroiditis (ICD-10 code: E06) E-6 process, a common photographic process for developing transparency film E6 protein, a protein encoded by Human papillomavirus Honda E6, one of the predecessors of Honda's ASIMO robot Motorola ROKR E6, a 2006 multimedia phone model Nokia E6, a smartphone

Transport Rail EMD E6, a diesel locomotive LNER Class E6, a class of British steam locomotives PRR E6, an American steam locomotive LB&SCR E6 class, a British steam locomotive E6 Series Shinkansen, a Japanese high-speed train

Road European route E6, a European highway route London Buses route E6, a Transport for London contracted bus route North–South Expressway Central Link, route E6 in Malaysia NAIA Expressway, route E6 in the Philippines Jōban Expressway, Sendai-Tōbu Road, Sanriku Expressway (between Sendaiko-kita IC and Rifu JCT) and Sendai-Hokubu Road, the E6 expressway in Japan BYD e6, an electric car by BYD Auto

Aviation Eurowings Europe (IATA code: E6), a Maltese airline subsidiary of Lufthansa E-6 Mercury, a US Navy derivative of the Boeing 707 Eggenfellner E6, an American aircraft engine design Pfalz E.VI, a World War I German aircraft

Other transport E6 European long distance path, a long-distance hiking trail

Music Electric Six, a Detroit rock band E6, the first note of the whistle register "E6", a song by Norwegian band D.D.E. The song title is a reference to the European route E6. Elephant 6, a collective of independent American musicians E6, the first note of Runaway (Kanye West song)

Other uses E6, nickname for the six biggest economies of the European Union: France, Germany, Italy, Poland, Netherlands and Spain E6, a London postcode district in the E postcode area E6, an error by the Shortstop in baseball E-6 (rank), the sixth rank of enlisted soldier in the US armed services E6 grade, of difficulty in rock climbing E6 (short for Epic 6), a variant of Dungeons & Dragons v3.5 E6 (character), a fictional character in the webtoon series Live with Yourself! e621 (website), a furry-themed image artboard website commonly abbreviated as "e6" E6 format, a temporary grouping of the largest EU countries to further the Savings and Investments Union

See also 6E (disambiguation)