Palmisano is an Italian surname. Notable people with the surname include:
Andrea Palmisano (born 1988), Italian male rower August Palmisano (1928–1978), American mobster and tavern owner Antonella Palmisano (born 1991), Italian racewalker Conrad Palmisano (1948–2024), American stuntman and film director Giuseppe Palmisano (born 1963), Italian lawyer Joe Palmisano (born 1954), American football player and coach Joe Palmisano (baseball) (1902–1971), American baseball player Linea Palmisano (born 1976), American politician Marcello Palmisano (1940–1995), Italian journalist and reporter Mario Palmisano (born 1978), Italian rower Samuel J. Palmisano (born 1951), American business executive, IBM Sean Ryan Palmisano, American Navy SEAL and podcaster Valentina Palmisano (born 1983), Italian politician Vincent L. Palmisano (1882–1953), American politician from Maryland