William Holt may refer to:
Politicians William Holt (fl.1397), MP for Launceston William Holt (died 1436), MP for Warwickshire William Holt (mayor) (1737–1791), mayor of Williamsburg, Virginia William Holte or Holt, MP for Clitheroe and Preston
Others William Holt (Jesuit) (1545–1599), rector of English College William Holt (writer) (1897–1977), English writer, artist and traveller Lt. William Holt, the main character in Medal of Honor: European Assault William Holt (cricketer) (1935–2024), former New Zealand cricketer William H. Holt (1842–1919), American judge Will Holt (1929–2015), writer and lyricist Willy Holt (1921–2007), American production designer William Mack Holt (1917–1942), American Navy sailor and naval aviator