Thomas or Tom Worthington may refer to:
Thomas Worthington (Douai) (1549–1627), English Catholic priest and third President of Douai College Thomas Worthington (Dominican) (1671–1754), English Dominican friar and writer Thomas Worthington (governor) (1773–1827), American Democratic-Republican politician from Ohio, 6th Governor of Ohio Thomas Contee Worthington (1782–1847), American lawyer, captain in War of 1812, member of the House of Representatives in Maryland Thomas Worthington (architect) (1826–1909), English architect Tom Worthington (computer programmer) (born 1957), Australian computer programmer Tom Worthington (footballer) (1866–?), Welsh international footballer
See also Thomas Worthington High School, Worthington, Ohio