Calamandrana is a comune (municipality) in the Province of Asti in the Italian region Piedmont, located about southeast of Turin and about southeast of Asti.

Calamandrana borders the following municipalities: Canelli, Cassinasco, Castel Boglione, Nizza Monferrato, Rocchetta Palafea, and San Marzano Oliveto.

People Giulio Cesare Cordara (1704–1785), historian and writer.

Twin towns Calamandrana is twinned with:

Kisapostag, Hungary

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