Great Southern Railway may refer to:
Buenos Aires Great Southern Railway, former railway in Argentina Journey Beyond, operator of The Ghan, Indian Pacific and The Overland interstate passenger trains in Australia Main Southern railway line, or Great Southern Railway, in New South Wales, Australia Great Southern Railway (South Gippsland), former railway serving the South Gippsland region in Victoria, Australia Great Southern Railway (Western Australia), railway branch from Northam to Albany in Western Australia Great Southern Railways (Ireland)
See also Great Southern (disambiguation) GSR (disambiguation) Southern Railway (disambiguation)