De Wert is a surname. Notable people with the surname include:
Giaches de Wert (1535–1596), Franco-Flemish composer Guido De Wert, retired academic and medical researcher Jean de Wert, French name for Johann von Werth (1591–1652), German cavalry general Lucas de Wert, half of Lucas & Steve, a Dutch house music duo formed in 2010 Richard De Wert (1931–1951), US Navy hospital corpsman posthumously awarded the Medal of Honor
See also Wert (disambiguation)